Mood and Metabolic Clinic


You have arrived at the Mood & Metabolic Clinic (MMC) page.  As Director of the clinic, I invite you to learn more about our clinical services and research opportunities.  Developed out of the recognition that mood disorders often co-occur with illnesses affecting the body’s metabolism, the MMC offers state-of-the-art expertise in managing complex presentations of depression and bipolar disorder that co-occur with “metabolic” disorders.  These conditions can include obesity, diabetes, heart disease, and the metabolic syndrome.  The MMC is believed to be the first outpatient program of its kind in the Midwest that is specifically devoted to the treatment and study of patients with mood disorders and co-occurring metabolic risk factors.

As a physician, I became interested in this area of psychiatry after learning that patients with major depression and bipolar disorder needlessly experience a shortened life expectancy from general medical problems that far too often go undiagnosed and undertreated.  My current clinical and research mission is to discover new treatments that not only reduce symptoms of depression and mania, but also improve general physical health and wellbeing.

All clinical intake appointments through our research program are offered at no cost.  We are able to underwrite the cost of this service through foundation grants and the generosity of individuals who have donated to the MMC.  For more information or to schedule an appointment, please call 216-844-2862.   We look forward to meeting you and your family, and to helping you achieve a healthier mind and body.


Martha Schinagle, M.D.

Assistant Professor of Psychiatry and Director of the Mood & Metabolic Clinic, UHCMC
Medical School – Case Western Reserve University
Residency – Massachusetts Mental Health Center 

Learn More About the Metabolic Syndrome

The metabolic syndrome is a group of risk factors that leads to the development of heart disease and diabetes.  Patients with bipolar disorder and depression can develop metabolic syndrome much earlier in life than individuals without a mood disorder.  Some researchers believe that the metabolic syndrome may contribute to the development of depressive symptoms.   The metabolic syndrome is easily measured by your physician or health care provider.  Click here for more information on metabolic syndromeheart disease, and the different kinds of mood disorders.

Are you at risk for early mortality from heart disease?  Follow the link below to estimate your 10-year risk of suffering a heart attack or dying from cardiovascular disease.
Framingham Risk Calculator

Are you at risk for depression or bipolar disorder?  Take an anonymous quiz to see if you are experiencing symptoms suggestive of a mood disorder.  

DBSA Mental Health Screening Center

Ongoing Clinical Research Studies

We are currently conducting a clinical trial to investigate whether a medication that is routinely used in the treatment of type 2 diabetes (eg. pioglitazone) can reduce symptoms of depression, reduce abdominal obesity, and improve other aspects of the metabolic syndrome.  To be eligible for participation, you must be diagnosed with a mood disorder and currently be experiencing symptoms of depression.  You will be assessed for these conditions at your clinical intake appointment.  Answers to some frequently asked questions about participation in the research study can be found below.  For more information or to schedule an appointment, please call 216-844-2862.

Questions About Clinical Trial Participation

1. Who is eligible to participate?
For clinical trials studying pioglitazone for the treatment of bipolar depression, men and women between the ages of 18 – 70 may participate.

2. Who is excluded from participation?
If you have a diagnosis of heart failure, you will not be eligible to participate.  Also, if you are pregnant or planning to become pregnant, you will not be able to enroll in this study.

3. How long will study participation last?
The study may last up to 8 weeks.

4. Is there a chance I will receive a placebo or “sugar pill”?
Yes. This study is being done to see if pioglitazone is a helpful and safe treatment for bipolar depression. We also want to see how it compares with placebo. A placebo pill is a pill that looks like the study medication but has no active ingredients.

5. Can I still participate if I do not have health insurance?
Yes.  All study-related visits are provided at no cost.  We also provide 3 routine clinical care visits over 3 months to all patients who participate in any of our research studies.  This helps to ensure a smooth transition from the point of exiting a clinical trial to beginning routine care.

6. How long will I have to wait before getting an appointment for an initial psychiatric evaluation?
We are typically able to schedule appointments with a physician within 2 weeks of your call.