Mood Disorder

The Mood Disorders Program is a patient-centered program, designed to meet each individual patient’s needs.  With a balanced approach of medication and psychotherapy, our expertly-trained team of clinical physicians is dedicated to ensuring that each patient has a wide range of treatment options.  Treatments and other services are offered in a variety of locations, including inpatient and outpatient settings.  With an emphasis on peer collaboration, clinical research, and continuing education, the Mood Disorders Program strives to provide effective and compassionate care that enables our patients to live healthier, fuller lives.

Why We Do What We Do

“We like what we do. We see it as a privilege to do what we do. We study mood disorders. We study bipolar disorder. We study how mood disorders present early in life and how they can be best treated. We believe that there are no miracle pills and that talking with people and helping them learn how to live with the symptoms of their illness makes a big difference. We try and come up with new ideas that make a difference. We think the patient is always right, even when they are wrong. We are here to make a contribution, to improve the lives of people and their families who suffer from and live with mood disorders.”  Joseph R. Calabrese, M.D.

Our Mission

To identify the causes of Bipolar Disorder and other mood disorders, to find effective treatment, and to discover a cure.

Our research is patient-centered. This means we have designed our research studies to improve the lives of people who choose to participate in them. Our research focuses on function and disability, not just symptom improvement.

News

• Keming Gao, associate professor in the Department of Psychiatry, was awarded a NARSAD Young Investigator Grant to support is research in the use of quetiapine-XR (Seroquel XR) as a treatment, alone or with antidepressant, to treat patients with anxiety disorders concurrent with major depressive disorder. Only 214 investigators worldwide earned this grant.

• New study compares bipolar medications, article on PsychCentral - article link

• In 2010 Dr. Kemp who was awarded the 2010 Gerald L. Klerman Young Investigator Award. This award is given annually to honor research contributions that support the Depression Bipolar Support Alliance’s (DBSA) mission: that being to improve the lives of people living with mood disorders. 

• Bipolar Diagnosis Eludes Many Who Suffer from the Disorder - article

• Transformation of Psychiatry into the Clinical Neuroscience of Mental Disorders: An Update for Advocates and Consumers - article |poster

• Joseph R. Calabrese, M.D. and the Center for Bipolar Disorder are working with Congresswoman Marcy Kaptur and the Department of Defense on the Kaptur DoD/DVA Mental Health Initiative. (Risk and Resilience Factors for Combat-Related Post-Traumatic Psychopathology and Post Combat Adjustment)

• Are Patients with Depression at Greater Risk for Diabetes and Heart Disease? (Article)

Mood and Metabolic Clinic 

 The Mood and Metabolic Clinic explores the relationship between metabolic syndrome and mood disorders.  Click here to access the Mood and Metabloic Clinic web page and learn more about it.

Our Team

The Mood Disorders Program is composed of both clinicians and researchers, all working together to provide patients and their families with the best possible care.

Joseph R. Calabrese, M.D.
Bipolar Disorders Research Chair & Prof. of Psychiatry
Co-Director, Bipolar Disorders Research Center
Director, Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2865
Fax: (216) 844-2875

Research Interests
Improvement of Clinical Outcomes in Under-served Populations of Bipolar Disorder, Including Those with Rapid Cycling, Children and Adolescents, Adults Currently Abusing Alcohol and/or Drugs, Forensic Complications of Bipolar Disorder, Those Receiving Care within Community Mental Health Centers, Older Adults, and Members of the Ohio National Guard and Reserve.

HONORS & AWARDS:

• 2012    Ohio Psychiatric Physicians Association Lifetime Achievement Award
• 2012    European Bipolar Forum Lifetime Achievement Award
• 2008    2008 Gerald L. Klerman Lifetime Achievement Award
• 2007    Awarded the Bipolar Disorders Research Chair
• 2004    NARSAD Lifetime Achievement Award

Peer-Reviewed Papers

• Has collaborated with 692 co-authors between 1990 and 2011
• Has been cited by 7,823 authors between 1990 and 2011
• Total citations:   5,582
• 21.7 citations per paper (mean in Psychiatry & Psychology is 8.24)
• 26 publications cited > 200 times as of 11/2011
• G-Index = 67
• H-Index = 38

Selected Publications (All Publications)

1. Calabrese JR, Delucchi GA: Spectrum of efficacy of divalproex in 55 rapid-cycling manic depressives. Am J Psychiatry 1990;147(4):431-4.
2. Calabrese JR, Bowden CL, Sachs GS, et al: A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 1999;60:79-88.
3. Calabrese JR, Suppes T, Bowden CL, et al: A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid cycling bipolar disorder. J Clin Psychiatry. 2000;61:841-50.
4. Ketter TA, Calabrese JR: Stabilization of mood from below versus above baseline in bipolar disorder: A new nomenclature. J Clin Psychiatry. 2002;63(2):146-151.
5. Calabrese JR, Bowden CL, Sachs G, et al: A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry. 2003;64:1013-1024.
6. Calabrese JR, Hirschfeld RMA, Frye MA, et al: Impact of depressive symptoms compared with manic symptoms in bipolar disorder: Results of a U.S. community-based sample. J Clin Psychiatry 2004;65:1499-1504.
7. Calabrese JR, Keck PE, Jr., Macfadden W, et al: A randomized, double-blind, placebo-controlled trial of quetiapine, in the treatment of bipolar I or II depression. Am J Psychiatry. 2005;162:1351-1360.
8. Calabrese JR, Shelton MD, Rapport DJ, et al: A 20-month, double-blind, maintenance trial of lithium vs. divalproex in rapid-cycling bipolar disorder. Am J Psychiatry. 2005;162:2152-2161.
9. Sachs GS, Nierenberg AA, Calabrese JR, et al: Effectiveness of adjunctive antidepressant treatment for bipolar depression: A double-blind placebo controlled study. N Engl Journal Med. 2007;356:1711-22.

Jera Barrett, MD
Psychiatrist
Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2400
Fax: (216) 844-2877

Darlene D. Foth, ATR-BC, PC, LSW
Clinical Coordinator, Intensive Outpatient Program
Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 844-2874
Fax: (216) 844-2836

Research Interests
Art therapy with Mood Disorder patients, Mind Body Spirit Connection & Wellness

Stephen J. Ganocy, Ph.D.
Director, Data Management & Statistical Analysis Unit
Bipolar Disorders Research Center
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2853
Fax: (216) 844-2875

Research Interests
Application of Statistics to Medical Psychiatry

Selected Publications
1. Ganocy, SJ. Estimation problems from data with change points. PhD Thesis, Case Western Reserve University, 2003.
2. Shim, SS, Hammonds, MD, Ganocy, SJ and Calabrese, JR. Effect of sub-chronic lithium treatment on synaptic plasticity in the dentate
gyrus of rat hippocampal slices. Progress in Neuropsychopharmacology and Biological Psychiatry 2007; 31:343-347.
3. Syamlal, G, Doney, D, Bang, KM, Greskevitch, M, Groce, D, Ganocy, S and Hoffman, W. Medical fitness evaluation for respirator users: Results of a national survey of private sector employers. Journal of Occupational and Environmental Medicine 2007; 49:691-699.
4. Sajatovic, M, Elhaj, O, Youngstrom, EA, Bilali, SR, Rapport, DJ, Ganocy, SJ and Calabrese, JR. Treatment adherence in individuals with rapid cycling bipolar disorder: Results from a clinical trial setting. Journal of Clinical Psychopharmacology 2007; 27:412-414.

Keming Gao, M.D., Ph.D.
Assistant Professor of Psychiatry
Department of Psychiatry
Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2656
Fax: (216) 844-2875

Research Interests
Multi-Morbid Mood Disorders, Phenomenology and Treatment of Comorbid Anxiety Disorder in Mood Disorders

Selected Publications (All Publications)
1. Gao K., Gajwani P., Elhaj O. and Calabrese JR. Typical and Atypical Antipsychotics in Bipolar Depression. J Clin Psychiatry 2005; 66: 1376-1385.
2. Gao K, Calabrese JR. Newer treatment studies for bipolar depression. Bipolar Disorders 2005; 7 (Suppl. 5):13-23.
3. Gao K, Muzina D, Gajwani P, Calabrese JR. Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review. J Clin Psychiatry 2006; 67:1327-1340.
4. Gao K, Ganocy SJ, Gajwani P, Muzina DJ, Calabrese JR. Sensitivity and Tolerability of Antipsychotics in Patients with Bipolar Disorder or Schizophrenia: Focus on Somnolence (J Clin Psychiatry, in press).

Steven P. Hampl, Ph.D.
Head, Psychotherapy Services, Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2400
Fax: (216) 844-2875

John A. Heather, M.D.
Assistant Professor of Psychiatry
Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2400

Suzanne M. Jarm, MSN, APRN, BC
Advanced Practice Nurse, Ambulatory (Adult) Psychiatry 
Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 844-2893
Fax: (216) 844-2836

David Kemp, M.D.
K-12 Research Scholar
Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2865
Fax: (216) 844-2875

Research Interests
Bipolar Depression; Pharmacological Treatment Trials; Mood Disorders and Comorbid General Medical Conditions; Metabolic Syndrome; Diabetes; Rating Scales and Diagnostic Assessment Instruments

Selected Publications (All Publications)
1. Kemp DE, Gao K, Muzina DJ, Gajwani P, Calabrese JR. Trial-based advances in the treatment of bipolar depression. Progress in Neurotherapeutics and Neuropsychopharmacology. 2007;2(1):193-212.
2. Kemp DE, Gilmer WS, Fleck J, Dago PL. An association of intrusive, repetitive phrases with lamotrigine treatment in bipolar II disorder. CNS Spectrums. 2007;12(2):106-111.
3. Kemp DE, Gilmer WS, Fleck J, Straus JL, Dago PL, Karaffa M. Aripiprazole augmentation in treatment-resistant bipolar depression: Early response and development of akathisia. Progress in Neuropsychopharmacology and Biological Psychiatry. 2007;31(2):574-7.
4. Calabrese JR, Muzina DJ, Kemp DE, Sachs GS, Thompson TR, Klingman D, Reed ML, Hirschfeld RM. Predictors of bipolar disorder risk among patients currently treated for major depression. Medscape General Medicine. 2006;8(3) [online journal].

Paul R. Minnillo, Ph.D.
Psychologist
Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 286-4360
Fax: (216) 844-2877

Research Interests
Mechanisms of Change in Psychotherapy, Motivational Interviewing, Optimizing Psychotherapy for Bipolar Disorder, Exercise and Health

Martha Schinagle, MD
Psychiatrist
Mood & Metabolic Clinic
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2400
Fax: (216) 844-2877
Website: http://cwrupsychiatry.org/forpatients/whoweserve/mood-disorder/mood-metabolic-clinic

Edwin R. Shirley, Ph.D.
Psychotherapy Services, Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 844-2400
Fax: (216) 844-2875 

Research Interests
Mood Disorders, Anxiety Disorders, Dual Diagnosis

Philip K. Chan, MS
Associate Director, Data Management & Statistical Analysis Unit
BA, Biochemistry and Molecular Biology, Boston University, MS, Biostatistics, Case Western Reserve University
Telephone: (216) 844-2817
Fax: (216) 844-2875

Carla Conroy, B.A. 
Data Management Assistant 
BA, Sociology - concentration in Criminology, Cleveland State University
Telephone: (216) 844-2871
Fax: (216) 844-2875

Nicole A. D'Arcangelo, MSW, LSW
Interviewer, Risk and Resilience Factors for Combat-Related Posttraumatic
Psychopathology and Post Combat Adjustment Project
MSW, The Ohio State University
B.S., Lake Erie College
Telephone: (216) 286-6541

Toyomi Goto, M.A.
Research Assistant
Clinical Psychology Specialization, Cleveland State University
Telephone: (216) 844-2862
Fax: (216) 844-2875

Mary Catherine Koehler, M.Ed.
Research Assistant II
Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2869
Fax: (216) 844-2875

Eve Laidman
Adm. Asst./J.R. Calabrese, M.D.
Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 844-2865
Fax: (216) 844-2875

Marcie Pollack
Patient Care Coordinator II/Clinical Secretary
Mood Disorders Program
University Hospitals Case Medical Center
Case Western Reserve University
Telephone: (216) 844-2400
Fax: (216) 844-2877

Kathy Sealey
Administrative Assistant
Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 844-2887
Fax: (216) 844-2875

Mary Beth Serrano, PCC
Research Operations Manager 
BA, Psychology, Bowling Green State University, MA, Counseling and Human Services, John Carroll University
Telephone: (216) 844-2861
Fax: (216) 844-2875

Renee Slembarski, B.A., CCRC
Administrator, Research Operations 
BA, Psychology, The College of Wooster
Telephone: (216) 844-2864
Fax: (216) 844-2875

Timothy H. Warneka, M.Ed., PCC-S
Research Coordinator
M.Ed., Counseling, Cleveland State University
B.S., Psychology, University of Dayton
Telephone: (216) 844-2863
Fax: (216) 844-2875

Abigail Williams
Project Coordinator B.S., Health Care Administration, Kent State University
Telephone: 216-844-2890
Fax: 216-844-2875

Teresa Young
Patient Access Representative
Mood Disorders Program
University Hospitals Case Medical Center
Telephone: (216) 844-2870
Fax: (216) 844-2875

Global Outreach

"A Commitment to Share Patient-Centered New Knowledge World-Wide"

Click here to view a map of the growing list of locations that have been visited by the Mood Disorders Program. To learn more about each location, click on the red pins. Use the navigation arrows and (+/-) signs to pan and zoom the map.

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